Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study
نویسندگان
چکیده
Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163(+)CD206(-) tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.
منابع مشابه
Ultraviolet A1 Phototherapy of Mycosis Fungoides
Received May 13, 2011, Revised July 30, 2011, Accepted for publication October 16, 2011 Corresponding author: Kee Suck Suh, Department of Dermatology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 602-702, Korea. Tel: 82-51-990-6145, Fax: 82-51-990-3041, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attrib...
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